Rhodium(II)-catalyzed intramolecular C-H insertion α- to oxygen: reactivity, selectivity and applications to natural product synthesis
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Coster, Mark J
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Abstract
The selective functionalisation of C-H bonds is a powerful strategy for the construction of organic molecules and the Rh(II)-catalysed C-H insertion reaction is a particularly robust and useful tool for this purpose. This review discusses the insertion of Rh(II) carbenes into C-H bonds that are activated by a-oxygen substituents, focusing on the trends that have been observed in reactivity and selectivity, and the applications of this reaction to the total synthesis of complex natural products.
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Organic & Biomolecular Chemistry
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13
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© 2015 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
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Medicinal and biomolecular chemistry
Organic chemistry
Organic chemical synthesis