Vasculogenesis is the de novo formation of blood vessels by mesodermal progenitors undergoing differentiation to endothelial cells. New vasculature formation from pre-existing vasculature occurs through the physiological remodelling process known as angiogenesis. Angiogenesis is implicated in the proliferation and growth of both physiologically normal and neoplastic tissues, through the establishment of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. Many inhibitory and promoter genes regulate this process, however the role of specific genes in the shift from normal angiogenesis to tumour initiation is complex and thus poorly understood. This book investigates the process of angiogenesis in malignancies. The functional role of key regulatory factors will be examined in the context of normal healthy condition. Then the association of these factors to disease and malignancy, cancer proliferation and progression will be discussed. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators will be investigated due to the great potential for exploitation in the development of a novel treatment for cancer.