Hasubanan Alkaloids with δ-Opioid Binding Affinity from the Aerial Parts of Stephania japonica

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Carroll, Anthony R
Arumugan, Thirumavalavan
Redburn, Joanne
Ngo, Ana
Guymer, Gordon P
Forster, Paul I
Quinn, Ronald J
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2010
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Abstract

Two new (1 and 2) and six known hasubanan alkaloids (3-8) and one morphinane alkaloid (9) were isolated from the leaves of the North Queensland rainforest vine Stephania japonica. The structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR spectra. The hasubanan alkaloids showed affinity for the human d-opioid receptor with IC50 values ranging from 0.7 to 46 卮 The compounds were also tested for their affinity to 孠and ?-opioid receptors and shown to be inactive against ?-opioid receptors, but were of similar potency against the 孯pioid receptor.

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Journal of Natural Products

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73

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5

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Chemical sciences

Biologically active molecules

Biological sciences

Biomedical and clinical sciences

Traditional, complementary and integrative medicine

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