Methodological progress note: Hybrid effectiveness-implementation clinical trials

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Ullman, Amanda J
Beidas, Rinad S
Bonafide, Christopher P
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2022
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Abstract

Randomized controlled trials (RCTs) remain the gold-standard approach to informing clinical decision-making and drawing causal inferences.1, 2 Yet, traditional RCTs have limitations.1-4 Conducting these trials can be painstakingly slow and translation to practice even slower, resulting in meaningful and unacceptable research-to-practice gaps. There is often a disconnect in generalizability and performance between the highly controlled clinical trials to the real-world application of approaches within complex health environments across situational contexts.

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Journal of Hospital Medicine

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17

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11

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© 2022 The Authors. Journal of Hospital Medicine published by Wiley Periodicals LLC on behalf of Society of Hospital Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Health services and systems

Nursing

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Life Sciences & Biomedicine

Medicine, General & Internal

General & Internal Medicine

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Ullman, AJ; Beidas, RS; Bonafide, CP, Methodological progress note: Hybrid effectiveness-implementation clinical trials, Journal of Hospital Medicine, 2022, 17 (11), pp. 912-916

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