Recently, big data (BD) has attracted researchers and practitioners due to its potential usefulness in decision-making processes. Big data analytics (BDA) is becoming increasingly popular among manufacturing companies as it helps gain insights and make decisions based on BD. However, there many barriers to the adoption of BDA in manufacturing supply chains. It is therefore necessary for manufacturing companies to identify and examine the nature of each barrier. Previous studies have mostly built conceptual frameworks for BDA in a given situation and have ignored examining the nature of the barriers to BDA. Due to the significance of both BD and BDA, this research aims to identify and examine the critical barriers to the adoption of BDA in manufacturing supply chains in the context of Bangladesh. This research explores the existing body of knowledge by examining these barriers using a Delphi-based analytic hierarchy process (AHP). Data were obtained from five Bangladeshi manufacturing companies. The findings of this research are as follows: (i) data-related barriers are most important, (ii) technology-related barriers are second, and (iii) the five most important components of these barriers are (a) lack of infrastructure, (b) complexity of data integration, (c) data privacy, (d) lack of availability of BDA tools and (e) high cost of investment. The findings can assist industrial managers to understand the actual nature of the barriers and potential benefits of using BDA and to make policy regarding BDA adoption in manufacturing supply chains. A sensitivity analysis was carried out to justify the robustness of the barrier rankings.