Interdisciplinarity is widely practised and theorised. However, relatively few studies have reflected on university-wide attempts to foster the concept. This article examines interdisciplinary teaching and learning at Griffith University, Australia. It reflects on the foundations of interdisciplinarity at the university and situates them within the broader context of innovations in worldwide practice; it draws from the literature on interdisciplinarity to traverse the broad understandings of the term; it discusses the Griffith University innovations implemented in support of the concept; and, it reports on the likely outcomes of current methods designed to improve interdisciplinary practice. Whilst challenging barriers to interdisciplinarity continue to exist, compounded by varied conceptions of what interdisciplinarity entails, positive learning and research outcomes have been accomplished at the university from its interdisciplinary foundations, which also provide a platform to go forward.