Prenylated Flavonoids from the Roots of Tephrosia rhodesica
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Muiva-Mutisya, Lois
Bogaerts, Jonathan
Duffy, Sandra
Valkonen, Arto
Heydenreich, Matthias
Avery, Vicky M
Rissanen, Kari
Erdélyi, Máté
Yenesew, Abiy
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Abstract
Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5-15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
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Journal of Natural Products
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© The Author(s) 2020. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine
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Atilaw, Y; Muiva-Mutisya, L; Bogaerts, J; Duffy, S; Valkonen, A; Heydenreich, M; Avery, VM; Rissanen, K; Erdélyi, M; Yenesew, A, Prenylated Flavonoids from the Roots of Tephrosia rhodesica, Journal of Natural Products, 2020