Effect of Definitions of Acute Gastroenteritis Episodes using Symptom Diaries in Paediatric Cohorts: A Systematic Review.
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Grimwood, Keith
Morley, Carla
Lambert, Stephen B
Ware, Robert S
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Abstract
Estimates of acute gastroenteritis (AGE) burden are difficult to compare between studies because of inconsistent definitions describing this illness. AGE definitions used in prospective, community-based childhood cohort studies were identified by searching databases for studies that collected daily observations of AGE symptoms. Disease definitions and refractory periods were extracted. Data from the Australian community-based Observational Research in Childhood Infectious Diseases (ORChID) birth cohort were used to calculate AGE incidence and duration using identified AGE definitions, and the World Health Organization definition for diarrhoea. Eight distinct AGE definitions were identified. All included loose stools and seven included vomiting as symptoms. The refractory period separating episodes ranged from 1 to 21 days. When applied to the ORChID dataset, AGE incidence ranged from 0.8 to 2.6 episodes per child-year-at-risk, a threefold relative difference. Direct comparisons of rates from different cohorts can only be undertaken if a standard definition for AGE is adopted.
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Journal of Pediatric Gastroenterology and Nutrition
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© 2019 Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Journal of Pediatric Gastroenterology and Nutrition, 2019. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.
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Biomedical and clinical sciences
Clinical sciences
Nutrition and dietetics
Paediatrics
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Citation
Mihala, G; Grimwood, K; Morley, C; Lambert, SB; Ware, RS, Effect of Definitions of Acute Gastroenteritis Episodes using Symptom Diaries in Paediatric Cohorts: A Systematic Review, Journal of Pediatric Gastroenterology and Nutrition, 2019, pp. 1-1