Student learning of effective care provision for people with chronic illness is an important component of pre-registration nursing curricula and demands specific knowledge and skills. This paper discusses the implementation of the combined pedagogy of unfolding case study and Mask-Ed™ high fidelity simulation within a 12 week unit on chronic illness in an Australian Bachelor of Nursing program. The unfolding case study develops clinical reasoning and decision making through facilitating students to progress through a case study as it develops in complexity. Mask-Ed™ is a high fidelity simulation technique in which a knowledgeable educator portrays an authentic character, but remains hidden from students by a silicone disguise. Using this combined pedagogy creates a unique and innovative opportunity to engage students in learning about the chronic illness experience. This pedagogy can support students to gain a holistic understanding of the psychosocial and physical health care needs of patients and their families and develop their therapeutic skills and clinical judgment. Integration of these interactive learning techniques has the potential to transform student learning about person-centred care within pre-registration curricula.