Denhaminols A−H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides

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Levrier, Claire
Sadowski, Martin C
Nelson, Colleen C
Healy, Peter C
Davis, Rohan A
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2015
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Eight new dihydro-߭agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.

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Journal of Natural Products
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78
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1
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© 2015 American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
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Chemical sciences
Biologically active molecules
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine
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