In this article I explore, through the analysis of ethnographic data, the demands of gender and place as they play themselves out in the lives of female injecting drug users (IDUs) in the rural communities of North Wales. The findings point to the array of role-relationships which women (attempt to) manage whilst also pursuing an IDU career and highlight how living in a rural community of place shapes how women attribute meaning to, and experience, injecting drug use. By incorporating theoretical ideas around gender performativity and gender spatiality, the analysis provides some understanding of how female IDUs construct their 'risk' behaviour within their own socially embedded and culturally meaningful discourses. The findings suggest the importance of an understanding of gender and place dynamics in the development of effective intervention strategies.