Default mode network activity in depression subtypes

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Borserio, Bernard J
Sharpley, Christopher F
Bitsika, Vicki
Sarmukadam, Kimaya
Fourie, Phillip J
Agnew, Linda L
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2021
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Abstract

Depression continues to carry a major disease burden worldwide, with limitations on the success of traditional pharmacological or psychological treatments. Recent approaches have therefore focused upon the neurobiological underpinnings of depression, and on the "individualization" of depression symptom profiles. One such model of depression has divided the standard diagnostic criteria into four "depression subtypes", with neurological and behavioral pathways. At the same time, attention has been focused upon the region of the brain known as the "default mode network" (DMN) and its role in attention and problem-solving. However, to date, no review has been published of the links between the DMN and the four subtypes of depression. By searching the literature studies from the last 20 years, 62 relevant papers were identified, and their findings are described for the association they demonstrate between aspects of the DMN and the four depression subtypes. It is apparent from this review that there are potential positive clinical and therapeutic outcomes from focusing upon DMN activation and connectivity, via psychological therapies, transcranial magnetic stimulation, and some emerging pharmacological models.

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Reviews in the Neurosciences

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32

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6

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© 2021 Walter de Gruyter & Co. KG Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

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Subject

Neurosciences

DMN

depression

diagnosis

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Borserio, BJ; Sharpley, CF; Bitsika, V; Sarmukadam, K; Fourie, PJ; Agnew, LL, Default mode network activity in depression subtypes, Reviews in the Neurosciences, 2021, 32 (6), pp. 597-613

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