Novel Therapeutics Targeting Cancer Stem Cell Surface Markers
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Ranaweera, CD
Maduwage, KP
Cheng, T
Islam, F
Gopalan, V
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Islam, Farhadul
Lam, Alfred K
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Abstract
Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs present within the tumor mass. CSC biomarker-specific targeted therapy has evolved during the past four decades and has shown promise in reducing tumor bulk, discouraging tumor metastasis, and improving sensitivity to chemo-/radiotherapy. The aim of this chapter is to discuss the novel therapeutics targeting CSCs surface markers. CSCs surface marker-targeted therapies in acute myeloid leukemia, hepatocellular cancer, gynecological cancer, non-small cell lung carcinoma, breast cancer, prostate cancer, brain malignancies, bladder cancer, and other malignancies will be discussed in detail.
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Cancer Stem Cells: Basic Concept and Therapeutic Implications
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1st
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This work is covered by copyright. You must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a specified licence, refer to the licence for details of permitted re-use. If you believe that this work infringes copyright please make a copyright takedown request using the form at https://www.griffith.edu.au/copyright-matters.
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Oncology and carcinogenesis
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Citation
Gamage, SK; Ranaweera, CD; Maduwage, KP; Cheng, T; Islam, F; Gopalan, V, Novel Therapeutics Targeting Cancer Stem Cell Surface Markers, Cancer Stem Cells: Basic Concept and Therapeutic Implications, 2023, 1st, pp. 167-198