Modern communication systems (Web 1.0, Web 2.0, cloud computing) and mobile wireless technologies (smartphones, iPads, monitoring devices) have, as with all industries, progressed in healthcare over recent years from being a minor, to being a very significant component of the environment. This paper will discuss how advancements in information technology, wireless communication systems and sensor technology have provided new opportunities concerning practices for managing Chronic Disease (CD). This paper will also address future software, touching on Web 3.0 and how, combined with Web 2.0 and cloud computing, has the potential to produce the ultimate architecture of participation. Understanding the benefits of such systems, devices and their increasing emergence and connection with modern healthcare settings, is vital for implementing future successful e-health solutions for people with CD.