Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.
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Seib, KL
Edwards, JL
Apicella, MA
McEwan, AG
Jennings, MP
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Abstract
Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
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Infection and Immunity
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73
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12
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© 2005 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Subject
Biological sciences
Bacteriology
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
Microbiology
Immunology
Medical microbiology