Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
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Kote-Jarai, Zsofia
Al Olama, Ali Amin
Giles, Graham G
Guy, Michelle
Severi, Gianluca
Muir, Kenneth
Hopper, John L
Henderson, Brian E
Haiman, Christopher A
Schleutker, Johanna
Hamdy, Freddie C
Neal, David E
Donovan, Jenny L
Stanford, Janet L
Ostrander, Elaine A
Ingles, Sue A
John, Esther M
Thibodeau, Stephen N
Schaid, Daniel
Park, Jong Y
Spurdle, Amanda
Clements, Judith
Dickinson, Joanne L
Maier, Christiane
Vogel, Walther
Doerk, Thilo
Rebbeck, Timothy R
Cooney, Kathleen A
Cannon-Albright, Lisa
Chappuis, Pierre O
Hutter, Pierre
Zeegers, Maurice
Kaneva, Radka
Zhang, Hong-Wei
Lu, Yong-Jie
Foulkes, William D
English, Dallas R
Leongamornlert, Daniel A
Tymrakiewicz, Malgorzata
Morrison, Jonathan
Ardern-Jones, Audrey T
Hall, Amanda L
O'Brien, Lynne T
Wilkinson, Rosemary A
Saunders, Edward J
Page, Elizabeth C
Sawyer, Emma J
Edwards, Stephen M
Dearnaley, David P
Horwich, Alan
Huddart, Robert A
Khoo, Vincent S
Parker, Christopher C
Van As, Nicholas
Woodhouse, Christopher J
Thompson, Alan
Christmas, Tim
Ogden, Chris
Cooper, Colin S
Southey, Melissa C
Lophatananon, Artitaya
Liu, Jo-Fen
Kolonel, Laurence N
Le Marchand, Loic
Wahlfors, Tiina
Tammela, Teuvo L
Auvinen, Anssi
Lewis, Sarah J
Cox, Angela
FitzGerald, Liesel M
Koopmeiners, Joseph S
Karyadi, Danielle M
Kwon, Erika M
Stern, Mariana C
Corral, Roman
Joshi, Amit D
Shahabi, Ahva
McDonnell, Shannon K
Sellers, Thomas A
Pow-Sang, Julio
Chambers, Suzanne
Aitken, Joanne
Gardiner, RA Frank
Batra, Jyotsna
Kedda, Mary Anne
Lose, Felicity
Polanowski, Andrea
Patterson, Briony
Serth, Juergen
Meyer, Andreas
Luedeke, Manuel
Stefflova, Klara
Ray, Anna M
Lange, Ethan M
Farnham, Jim
Khan, Humera
Slavov, Chavdar
Mitkova, Atanaska
Cao, Guangwen
Easton, Douglas F
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Abstract
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 10-8 to P = 2.7 10-33).
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Nature Genetics
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41
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10
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© 2009 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
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Biological sciences
Biomedical and clinical sciences
Oncology and carcinogenesis not elsewhere classified