Facile synthesis of core intermediates toward sialyl nucleoside mimetics

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Kwon, Hyeok Beom
von Itzstein, Mark
Jung, Kang-Yeoun
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2009
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Abstract

6-Deoxyphosphonated intermediates, 8 and 12, were efficiently synthesized from D-fructose and sucrose, respectively. These novel intermediates will be useful to synthesize various D-tagato- and fructofuranoside derivatives as inhibitors of sialyl transferase or sialidase.

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Tetrahedron Letters

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50

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21

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Medicinal and biomolecular chemistry

Biologically active molecules

Organic chemistry

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