Corymbones A and B, Phloroglucinols with Thyrotropin Releasing Hormone Receptor 2 Binding Affinity from the Flowers of Corymbia peltata

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Carroll, Anthony R
Urban, Sylvia
Lamb, Jasmine
Moni, Roger
Guymer, Gordon P
Forster, Paul I
Quinn, Ronald J
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Kinghorn, Douglas A.

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2008
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Abstract

High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC50 values of 23 and 19 卬 respectively.

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Journal of Natural Products

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71

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5

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© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page after publication. Use hypertext link above to access the ACS website.

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Chemical sciences

Biological sciences

Biomedical and clinical sciences

Traditional, complementary and integrative medicine

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