Bioreactor Design for Tendon/Ligament Engineering

No Thumbnail Available
File version
Author(s)
Wang, Tao
Gardiner, Bruce S
Lin, Zhen
Rubenson, Jonas
Kirk, Thomas B
Wang, Allan
Xu, Jiake
Smith, David W
Lloyd, David G
Zheng, Ming H
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2013
Size
File type(s)
Location
License
Abstract

Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.

Journal Title

Tissue Engineering

Conference Title
Book Title
Edition
Volume

19

Issue

2

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Biochemistry and cell biology

Biomedical engineering

Biomedical engineering not elsewhere classified

Persistent link to this record
Citation
Collections