Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

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Krssak, Martin
Lindeboom, Lucas
Schrauwen-Hinderling, Vera
Szczepaniak, Lidia S
Derave, Wim
Lundbom, Jesper
Befroy, Douglas
Schick, Fritz
Machann, Juergen
Kreis, Roland
Boesch, Chris
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2020
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Abstract

1 H-MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of 1 H-MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.

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NMR in Biomedicine

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© 2020 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Medicinal and biomolecular chemistry

Biomedical engineering

Clinical sciences

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Life Sciences & Biomedicine

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Biophysics

Radiology, Nuclear Medicine & Medical Imaging

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Krssak, M; Lindeboom, L; Schrauwen-Hinderling, V; Szczepaniak, LS; Derave, W; Lundbom, J; Befroy, D; Schick, F; Machann, J; Kreis, R; Boesch, C, Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations, NMR in Biomedicine, 2020

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