Paralleling the growth of the U.S. criminal justice system in recent decades, American families have increasingly experienced a social disaster of parents, and subsequently their children, undergoing imprisonment. Adopting a life course perspective to examine the likely drivers of the intergenerational transmission of offending and incarceration, we contextualize the development of antisocial behavior in an era of mass imprisonment. In doing so, we draw from the literature on the sociology of disasters to examine how traumas related to intergenerational incarceration may be both understood and ameliorated through appropriate policies and interventions. We argue that it is possible to better frame how risk factors for antisocial behavior, such as prenatal maternal stress, exposure to trauma, and deviant peer groups, may be integrated with factors that promote resilience and recovery. This includes improving safety, self-efficacy, and connectedness to prevent intergenerational offending and incarceration and facilitate desistance. By framing mass incarceration as a social disaster, a multifaceted, comprehensive approach takes on new urgency so as to reduce the prevalence of intergenerational offending and incarceration among millions of families in the United States.