Additive manufacturing of metal-organic frameworks (MOFs) using 3D printing has seen tremendous growth due to their excellent characteristics including high porosity, low cost, wide structural tunability, and easy processibility. To date, 3D-printing technology is adaptable, feasible, and customizable for the development of real-time sensors for industrial applications. By tuning the physio-chemical properties of organic polymers, inorganic metals, and ceramic materials, sensor architectures can be designed due to their porous surface, high surface area, high-density active sites, catalytic activity, and highly ordered coordination system with metals and polymers. In comparison with MOFs, conjugated organic semiconductor MOFs offer high molecular transport and sensing capability due to their being charge carriers and their specific ion interaction of the polymer with the host ions. Conjugated polymers offer electrochemical, light emitting, and light absorbing properties which is a great platform for detecting ions with high selectivity and sensitivity in the natural environment. On the other hand, the unique structure of MOFs and their distinct properties focus more on the development of automotive sensors. Complex assembly of 3D MOFs using nanomaterial formulations with organic ligands provides exciting sensing properties. In this chapter, we outline advances in the inclusion of 3D-printed MOFs and their design architecture, structure-property relationships, processing of functional nanocomposite materials, conjugated polymer-based MOFs, and their printing parameters for sensing in biological, physical, agricultural, and industrial applications.