Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics

No Thumbnail Available
File version
Author(s)
Stewart, Glenn
Johnson, Bruce
Balmain, Bryce
Shino, Kenji
Yamada, Akira
Morris, Norman
Chan, Jonathan
Sabapathy, Surendran
Primary Supervisor
Other Supervisors
Editor(s)
Date
2018
Size
File type(s)
Location
License
Abstract

Introduction: Ageing is associated with a progressive stiffening of the pulmonary vasculature that causes an increase in pulmonary vascular resistance and a decrease in compliance. It remains unclear if right ventricular myocardial mechanics adapt in response to age-related remodeling in the pulmonary vasculature.

PURPOSE: Accordingly, this study examined global and transmural longitudinal myocardial tissue deformation (strain) in a cohort of healthy young and middle-aged men to characterize age-related changes in myocardial tissue mechanics.

METHODS: Two-dimensional echocardiography was used to measure left (LV) and right (RV) ventricular strain in 10 young men (YM; Age: 27 ± 2yr, BMI: 23.2 ± 2.4m2) and 10 middle aged men (MAM; Age: 61 ± 7yr, BMI: 25.9 ± 3.2m2). A transmural strain gradient was calculated as the difference between endocardial and epicardial strain as an index of regional non-uniformity.

RESULTS: Systemic blood pressure was similar in young and middle aged men (YM: 118 ± 4mmHg vs MAM: 122 ± 4mmHg, p > 0.05), while echocardiographic estimates of pulmonary blood pressure via the tricuspid regurgitation pressure gradient were greater in middle aged men (YM: 17 ± 4mmHg vs MAM: 25 ± 6mmHg, p < 0.05). LV and RV dimensions were similar (p > 0.05) in young (LV EDV: 118 ± 19mL; RV EDA: 18.3 ± 2.2cm2) and middle aged men (LV EDV: 118 ± 17mL; RV EDA: 17.3 ± 3.8cm2). LV global longitudinal strain (YM: -17.5 ± 1.0% vs MAM: -18.0 ± 1.0%, p > 0.05) was similar in young and middle aged men, while RV global longitudinal strain (YM: -27.3 ± 1.8% vs MAM: -22.5 ± 1.7%, p<0.01) was lower in middle aged men. LV transmural strain gradient (YM: -4.6 ± 0.4% vs MAM: -4.6 ± 0.4%, p > 0.05) was similar in young and middle aged men, while RV transmural strain gradient (YM: -1.1 ± 0.4% vs MAM: -5.5 ± 0.5%, p<0.01) was higher in middle aged men.

CONCLUSION: Ageing was associated with global and regional alterations in RV myocardial mechanics, while LV function was unaltered. Specifically, ageing resulted in a decrease in RV global strain and an increase in transmural non-uniformity (i.e., increased transmural strain gradient). Differences in LV and RV myocardial architecture and age-related changes in the pulmonary vasculature are possible explanations for opposing LV and RV functional remodeling in response to ageing.

Journal Title
Conference Title
Medicine & Science in Sports & Exercise
Book Title
Edition
Volume
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Sports science and exercise
Medical physiology
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Sport Sciences
Persistent link to this record
Citation
Stewart, G; Johnson, B; Balmain, B; Shino, K; Yamada, A; Morris, N; Chan, J; Sabapathy, S, Ageing Alters Right Ventricular But Not Left Ventricular Myocardial Mechanics, Medicine & Science in Sports & Exercise, 2018, 50 (5), pp. 189-189