Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: synthesis, in vitro binding, and molecular modeling
No Thumbnail Available
File version
Author(s)
Banister, Samuel D
Moussa, Iman A
Jordan, Meredith JT
Coster, Mark J
Kassiou, Michael
Moussa, Iman A
Jordan, Meredith JT
Coster, Mark J
Kassiou, Michael
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2010
Size
File type(s)
Location
License
Abstract
Isomeric oxo-bridged analogs of aza-trishomocubane sigma (s) receptor ligands were synthesized and shown to display a reduced affinity for the s receptor. In the case of phenethyl derivative 4, there was a concomitant introduction of high-affinity for the a2C adrenergic receptor, and moderate affinity for the dopamine transporter. Molecular modeling was undertaken to rationalize these results.
Journal Title
Bioorganic & Medicinal Chemistry Letters
Conference Title
Book Title
Edition
Volume
20
Issue
1
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry
Pharmacology and pharmaceutical sciences