Bi-SGTAR: A simple yet efficient model for circRNA-disease association prediction based on known association pair only

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Li, S
Chen, Q
Liu, Z
Pan, S
Zhang, S
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2024
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Abstract

Identifying circRNA (circular RNA) associated with diseases holds promise as diagnostic and prognostic biomarkers, offering potential avenues for novel therapeutics. Several computational methods have been designed to predict circRNA-disease associations. Unfortunately, current computational models face issues stemming from the integration of data from multiple sources, leading to blind spots in data combination and increased model complexity. Thus, this article introduces a novel method named Bi-SGTAR (Bi-view Sparse Gating and True Association Regression). Notably, Bi-SGTAR demonstrates comparable performance to existing multi-source information fusion methods while utilizing only known circRNA-disease association pairs. In contrast to previous methods, the model divides the adjacency matrix into two views and employs an encoder with sparse gating to assess the reliability of all associations. Additionally, a supervised reconstructor is employed to define the true association probability, quantifying the truthfulness of all associations. The Encoding-Reconstruction-Regression (ERR) framework adeptly merges both reliable and truthful associations from both views. The experimental results unequivocally show that Bi-SGTAR surpasses state-of-the-art models across seven circRNA-disease datasets, one lncRNA-disease dataset, and one microbe-drug dataset, with fewer data needed.

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Knowledge-Based Systems

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291

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This work is covered by copyright. You must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a specified licence, refer to the licence for details of permitted re-use. If you believe that this work infringes copyright please make a copyright takedown request using the form at https://www.griffith.edu.au/copyright-matters.

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Bioinformatics and computational biology

Nanobiotechnology

Artificial intelligence

Data management and data science

Machine learning

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Li, S; Chen, Q; Liu, Z; Pan, S; Zhang, S, Bi-SGTAR: A simple yet efficient model for circRNA-disease association prediction based on known association pair only, Knowledge-Based Systems, 2024, 291, pp. 111622

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