Anti-Influenza virus drug design: Sialidase inhibitors

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Dyason, JC
von Itzstein, M
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2001
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Abstract

This review will give an overview of the design process behind the development of sialidase inhibitors, which can be used as anti-influenza drugs. Two drugs (Relenza頡nd Tamiflu驠are already available as prescription drugs and a third (BCX-1812) is currently undergoing third-phase clinical trials. Also, the use of molecular-modelling techniques in the understanding of the mechanism and the prediction of inhibition of this enzyme is reviewed.

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Australian Journal of Chemistry

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54

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11

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Chemical sciences

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