Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry

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Wilkinson, Brendan L
Bornaghi, Laurent F
Lopez, Marie
Healy, Peter C
Poulsen, Sally-Ann
Houston, Todd A
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2010
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Abstract

We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides.

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Australian Journal of Chemistry

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63

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5

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Chemical sciences

Biologically active molecules

Engineering

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