Leisure tourism, including destination choice, can be viewed as an investment in mental health maintenance. Destination marketing measures can thus be analyzed as mental health investment prospectuses, aiming to match tourist desires. A mental health framework is particularly relevant for parks and nature tourism destinations, since the benefits of nature for mental health are strongly established. We test it for one globally iconic destination, using a large-scale qualitative approach, both before and during the COVID-19 pandemic. Tourists’ perceptions and choices contain strong mental health and well-being components, derived largely from autonomous information sources, and differing depending on origins. Parks agencies emphasize factual cognitive aspects, but tourism enterprises and destination marketing organizations use affective approaches appealing to tourists’ mental health.