Thioamide Derivative of the Potent Antitubercular 2-(Decylsulfonyl)acetamide is Less Active Against Mycobacterium tuberculosis, but a More Potent Antistaphylococcal Agent

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Sun, Hsien-Kuo
Pang, Angel
Farr, Dylan C
Mosaiab, Tamim
Britton, Warwick J
Anoopkumar-Dukie, Shailendra
Grice, I Darren
Kiefel, Milton J
West, Nick P
Grant, Gary D
Houston, Todd A
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2018
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Abstract

Due to the prevalence of thioamides in antibacterial compounds, we chose to convert the amide in the antitubercular compound 2-(decylsulfonyl)acetamide to a thioamide using Lawesson’s reagent to study its activity against a range of microorganisms. This derivative (8) had significantly diminished activity against tuberculosis but slightly better activity than the parent compound against the Gram positive species Staphylococcus aureus. This activity against a second major pathogen is remarkable considering the structural simplicity of these compounds.

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Australian Journal of Chemistry

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71

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9

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Chemical sciences

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Engineering

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