Metal and organic pollutants are prominent marine contaminants that disperse widely throughout the environment. Some contaminants biomagnify, leaving long-lived apex predators such as cetaceans at risk of toxicity. Various tissues collected post-mortem from 16 Ziphiidae individuals that stranded on the New South Wales (NSW) coast, Australia, over ∼15 years were investigated for 16 metals/metalloids and 33 organic contaminants. Polychlorinated biphenyls (PCBs) and Dichlorodiphenyltrichloroethanes (DDTs) were commonly detected in blubber and liver tissues. Mercury, cadmium and silver exceeded reported toxicity thresholds in several individuals. The liver tissue of a Mesoplodon layardii specimen had the highest mercury (386 mg/kg dry weight). Liver tissue of a Mesoplodon grayi specimen had the highest silver concentration (19.7 mg/kg dry weight), and the highest cadmium concentration was in Ziphius cavirostris kidney (478 mg/kg dry weight). This study provides important new information for rare Ziphiidae species globally.