Vedolizumab-Induced Acute Interstitial Nephritis in Ulcerative Colitis

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Subhaharan, Deloshaan
Ramaswamy, Pradeep K
Francisco, Sewwandi
Ishaq, Naveed
Griffith University Author(s)
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2022
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http://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract

Vedolizumab is used in the treatment of inflammatory bowel disease and is generally well tolerated. We report a 20-year-old man who presented with right flank pain on a background of ulcerative colitis. He was on vedolizumab with his last dose 1 week before the onset of symptoms. Kidney function tests revealed a serum creatinine of 171 μmoL/L and a C-reactive protein of 74 mg/L. Kidney biopsy demonstrated focal acute interstitial nephritis. He was prescribed oral prednisolone and achieved complete recovery of renal function within 3 weeks. At the follow-up after 4 months, his renal function remains normal.

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ACG Case Reports Journal
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© 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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Gastroenterology and hepatology
Science & Technology
Life Sciences & Biomedicine
UROLOGIC COMPLICATIONS
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Subhaharan, D; Ramaswamy, PK; Francisco, S; Ishaq, N, Vedolizumab-Induced Acute Interstitial Nephritis in Ulcerative Colitis, ACG Case Reports Journal, 2022, 9 (6), pp. e00788
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