Tetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies

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Khan Haleel, A
Mahendiran, D
Rafi, UM
Veena, V
Shobana, S
Rahiman, AK
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2018
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Abstract

A series of mononuclear nickel(II), copper(II) and zinc(II) complexes of the type [ML1‒3Cl2] (1–9) have been synthesized and characterized. All the complexes interact with CT–DNA through groove mode of binding and bring about prominent nuclease activity on plasmid DNA. The complexes strongly inhibit the topoisomerase I, and also strongly interact with cyclin-dependent kinase receptor. The cytotoxicity activity were assessed aganist three human cancer cell lines such as lung (A549), cervical (HeLa) and colon (HCT–15), in which the complex 5 shows highest activity against the colon (HCT-15) cancer cell. The apoptotic studies were also reported.

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Inorganic and Nano-Metal Chemistry
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Inorganic chemistry
Oncology and carcinogenesis
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Khan Haleel, A; Mahendiran, D; Rafi, UM; Veena, V; Shobana, S; Rahiman, AK, Tetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies, Inorganic and Nano-Metal Chemistry, 2018, 48 (12), pp. 569-582
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