Adrenal Hemorrhage in a Cortisol-Secreting Adenoma Caused by Antiphospholipid Syndrome Revealed by Clinical and Pathological Investigations: A Case Report
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Abe, Ichiro
Yamazaki, Yuto
Nagata, Mai
Senda, Yuki
Takeshita, Kaori
Koga, Midori
Yamao, Yuka
Shigeoka, Toru
Kudo, Tadachika
Fukuhara, Yuichiro
Miyajima, Shigero
Taira, Hiroshi
Haraoka, Shoji
Lam, Alfred K.
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Abstract
Due to its rarity, adrenal hemorrhage is difficult to diagnose, and its precise etiology has remained unknown. One of the pivotal mechanisms of adrenal hemorrhage is the thrombosis of the adrenal vein, which could be due to thrombophilia. However, detailed pathological evaluation of resected adrenal glands is usually required for definitive diagnosis. Here, we report a case of a cortisol-secreting adenoma with concomitant foci of hemorrhage due to antiphospholipid syndrome diagnosed both clinically and pathologically. In addition, the tumor in this case was pathologically diagnosed as cortisol-secreting adenoma, although the patient did not necessarily fulfill the clinical diagnostic criteria of full-blown Cushing or sub-clinical Cushing syndrome during the clinical course, which also did highlight the importance of detailed histopathological investigations of resected adrenocortical lesions.
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Frontiers in Endocrinology
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12
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© 2022 Ochi, Abe, Yamazaki, Nagata, Senda, Takeshita, Koga, Yamao, Shigeoka, Kudo, Fukuhara, Miyajima, Taira, Haraoka, Ishii, Takashi, Lam, Sasano and Kobayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Clinical sciences
adrenal hemorrhage
antiphospholipid syndrome
cortisol-secreting adenoma
thrombophilia
thrombosis
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Ochi, K; Abe, I; Yamazaki, Y; Nagata, M; Senda, Y; Takeshita, K; Koga, M; Yamao, Y; Shigeoka, T; Kudo, T; Fukuhara, Y; Miyajima, S; Taira, H; Haraoka, S; Lam, AK; et al., Adrenal Hemorrhage in a Cortisol-Secreting Adenoma Caused by Antiphospholipid Syndrome Revealed by Clinical and Pathological Investigations: A Case Report, Frontiers in Endocrinology, 2021, 12, pp. 769450