The interest in developing clean and environmentally-friendly energy devices to be used on vehicles is intensifying because of emissions from conventional internal combustion engines considered as one of the significant contributors to the rapidly changing climate. Fuel cell energy devices, especially the proton exchange membrane (PEM) type, are the solid contender to replace the conventional vehicle propulsion technology in the transport sector. The PEM fuel cell technology needs a lot of efforts to overcome some existing problems such as durability, hydrogen storage, and cost for its successful worldwide commercialisation. This chapter deals with the durability, cost, and performance challenges related to the utilization of PEM fuel cell technology in electrified transportation. Recent advancements concerning the current challenges have been discussed. Moreover, issues of hydrogen storage and infrastructure are outlined.