Aims: To investigate aspects of the reliability and validity of the Work-related Subjective Experiences Scale (WSE-38), an instrument designed to help mental health professionals tailor mental health care to reduce employment restrictions. Methods: Sixty community residents with schizophrenia or schizoaffective disorder were recruited from a register of previous research participants in an existing genetics study of people with schizophrenia. The WSE-38 was administered via telephone interview, repeated two-five days later. Short-cycle test-retest reliability, internal structure, and concurrent validity were assessed. Face validity, utility, consumer and clinician acceptability were examined qualitatively. Findings: Short cycle test-retest reliability for most items and the total score were found to be good to very good. Items with low reliability were removed. Concurrent validity was promising with respect to a range of relevant measures. Face validity, client acceptability, and user utility were adequate. Further scale development and modifications to administration instructions are indicated. Conclusions: These results support further scale development and inform how it can be used for its intended purpose. Sensitivity to real change and predictive validity require ongoing investigation.