Non-equilibrium plasma prevention of Schistosoma japonicum transmission

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Wang, Xing-Quan
Wang, Feng-Peng
Chen, Wei
Huang, Jun
Bazaka, Kateryna
Ostrikov, Kostya Ken
Griffith University Author(s)
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2016
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Abstract

Schistosoma japonicum is a widespread human and animal parasite that causes intestinal and hepatosplenic schistosomiasis linked to colon, liver and bladder cancers, and anemia. Estimated 230 million people are currently infected with Schistosoma spp, with 779 million people at risk of contracting the parasite. Infection occurs when a host comes into contact with cercariae, a planktonic larval stage of the parasite, and can be prevented by inactivating the larvae, commonly by chemical treatment. We investigated the use of physical non-equilibrium plasma generated at atmospheric pressure using custom-made dielectric barrier discharge reactor to kill S. japonicum cercariae. Survival rate decreased with treatment time and applied power. Plasmas generated in O2 and air gas discharges were more effective in killing S. japonicum cercariae than that generated in He, which is directly related to the mechanism by which cercariae are inactivated. Reactive oxygen species, such as O atoms, abundant in O2 plasma and NO in air plasma play a major role in killing of S. japonicum cercariae via oxidation mechanisms. Similar level of efficacy is also shown for a gliding arc discharge plasma jet generated in ambient air, a system that may be more appropriate for scale-up and integration into existing water treatment processes.

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Scientific Reports

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6

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1

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© The Author(s) 2016. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Oncology and carcinogenesis

Medical parasitology

Science & Technology

Multidisciplinary Sciences

Science & Technology - Other Topics

DIELECTRIC BARRIER DISCHARGE

INACTIVATION

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Wang, X-Q; Wang, F-P; Chen, W; Huang, J; Bazaka, K; Ostrikov, KK, Non-equilibrium plasma prevention of Schistosoma japonicum transmission, Scientific Reports, 2016, 6 (1)

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