Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives
No Thumbnail Available
File version
Author(s)
Griffiths, Lyn
Nyholt, D.
Curtain, R.
Gaffney, Philip
Morris, B.
Nyholt, D.
Curtain, R.
Gaffney, Philip
Morris, B.
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
1995
Size
File type(s)
Location
License
Abstract
- The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations. 2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives. 3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.
Journal Title
Clinical and Experimental Pharmacology & Physiology
Conference Title
Book Title
Edition
Volume
22
Issue
6-Jul
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Physiology
Pharmacology and Pharmaceutical Sciences
Medical Physiology