A knowledge-to-practice gap has been widely documented in autism spectrum disorder (ASD) early intervention, including nonuse of effective practices and use of ineffective and/or non-evidence-based practices (non-EBPs). We argue that it is critical to bridge this gap to ensure the best possible outcomes for children with ASD. In this paper, we draw from the implementation science field to describe a strategic framework for disseminating information, improving practice, and maintaining EBPs in ASD early intervention centers that encompasses the entire cycle of the knowledge-to-action (KTA) paradigm with stakeholder collaboration as a key element. We outline the potential for application of the KTA framework and for planning and implementing a strategy for professional development in ASD early intervention centers in an Australian context with reference to the National Disability Insurance Scheme (NDIS). We provide a model for future research in ASD to facilitate the translation of research to practice in a more timely and efficient manner, in order to improve practice and outcomes for children with ASD and their families.