Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro

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Mpala, Lindiwe Nomathemba
Chikowe, Getmore Rumbudzai
Cock, Ian Edwin
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2021
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Introduction: The recent development of extensively antibiotic resistant bacteria has necessitated the search for novel antibacterial compounds. An examination of aromatic plants and traditional medicines is an attractive option for drug discovery. Astrotrichia latifolia Benth. is a native Australia shrub that has yet to be tested for antibacterial activity. Methods: The ability of A. latifolia leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: A. latifolia leaf methanolic and aqueous extracts were completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were non-toxic in the Artemia nauplii bioassay following 24 h exposure. Conclusion: A. latifolia leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.

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Pharmacognosy Communications

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11

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1

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© The Author(s) 2021. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

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Plant Biology

Pharmacology and Pharmaceutical Sciences

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Mpala, LN; Chikowe, GR; Cock, IE, Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro, Pharmacognosy Communications, 2021, 11 (1), pp. 40-44

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