Conductive electroactive polymers are materials discovered just on two decades ago. Originally heralded for their high conductivity/weight ratio, it is the unique chemical properties they possess that now arouse much attention. The ability to synthesise these materials under mild conditions enables a range of biological moieties (enzymes, antibodies and even whole living cells) to be incorporated into the polymer structure. The unique electronic properties then allow direct and interactive communication with the biochemistries incorporated to produce a range of analytical signals. This work reviews the options available for immobilisation of biocomponents and signal generation using conducting polymer-based biosensors.