Structural and Functional Insight Into the Glycosylation Impact Upon the HGF/c-Met Signaling Pathway

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Hu, Xinyue
Tang, Feiyu
Liu, Peilin
Zhong, Taowei
Yuan, Fengyan
He, Quanyuan
von Itzstein, Mark
Li, Hao
Weng, Liang
Yu, Xing
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Upon interactions with its specific ligand hepatocyte growth factor (HGF), the c-Met signal is relayed to series of downstream pathways, exerting essential biological roles. Dysregulation of the HGF-c-Met signaling pathway has been implicated in the onset, progression and metastasis of various cancers, making the HGF-c-Met axis a promising therapeutic target. Both c-Met and HGF undergo glycosylation, which appears to be biologically relevant to their function and structural integrity. Different types of glycoconjugates in the local cellular environment can also regulate HGF/c-Met signaling by distinct mechanisms. However, detailed knowledge pertaining to the glycosylation machinery of the HGF-c-Met axis as well as its potential applications in oncology research is yet to be established. This mini review highlights the significance of the HGF-c-Met signaling pathway in physiological and pathological context, and discusses the molecular mechanisms by which affect the glycosylation of the HGF-c-Met axis. Owing to the crucial role played by glycosylation in the regulation of HGF/c-Met activity, better understanding of this less exploited field may contribute to the development of novel therapeutics targeting glycoepitopes.

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Frontiers in Cell and Developmental Biology

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© 2020 Hu, Tang, Liu, Zhong, Yuan, He, von Itzstein, Li, Weng and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hu, X; Tang, F; Liu, P; Zhong, T; Yuan, F; He, Q; von Itzstein, M; Li, H; Weng, L; Yu, X, Structural and Functional Insight Into the Glycosylation Impact Upon the HGF/c-Met Signaling Pathway, Frontiers in Cell and Developmental Biology, 2020, 8