Titanium (Ti) and its alloys have been used for many decades as bone implants, due to their corrosion resistance and appropriate biomechanical properties. Successful implantation may depend on effective osseointegration, requiring biocompatibility of the material and attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nanoscale topography have been suggested to be critical. In this study, we present engineering of new bone drug-releasing implants, based on 3D-printed Ti-alloy (Ti6Al4V), with a unique dual topography composed of micron-sized spherical particles and vertically aligned titania nanotubes (TNT). The implants were prepared by a combination of two engineering technologies: laser 3D printing of Ti-alloy and electrochemical anodization processes to generate TNT on surface as nano-reservoirs for drug loading and improved interaction with bone cells. To further improve biocompatibility of prepared implants, their modification with hydroxyapatite was performed. The prepared implants were demonstrated for drug delivery applications by loading different therapeutic agents (e.g. antibacterial and anticancer). The results revealed successful drug loading and in-vitro release from TNT-3D-Ti implants. In addition, we studied the compatibility of the prepared implants using fibroblasts. Moreover, antibacterial properties of drug loaded implants were investigated in-vitro. This fabrication approach allows printing of specific implant geometries to meet custom surgical needs, coupled with the ability to release therapeutics locally. This custom printed TNT-3D-Ti implants combined with their localized drugreleasing capabilities have considerable potential to address multiple challenges for current bone implant technology and to improve bone therapy