Convenient access to novel functionalized pyrazino[1,2-b] isoquinolin-6-one and diazepino[1,2-b]isoquinolin-7-one scaffolds via the Cushman multicomponent reaction followed by post-condensation

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Sarnpitak, Pakornwit
Krasavin, Mikhail
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2014
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Abstract

Post-multicomponent reaction modifications of Cushman reaction-derived 1,2,3,4-tetrahydroisoquinolin-4-carboxylic acids turned out to be a surprisingly underdeveloped strategy in scaffold-oriented synthesis. In this Letter, we describe a concise synthesis of hitherto unreported pyrazino- and diazepino-fused isoquinolones in two chemical operations. The synthesis involves the use, for the first time, of aryl glyoxals as carbonyl components for the Cushman multicomponent reaction.

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Tetrahedron Letters

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55

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14

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Organic Chemistry not elsewhere classified

Medicinal and Biomolecular Chemistry

Organic Chemistry

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