Despite the successful efforts at curtailing the recent COVID-19 pandemic, the persistent threat of long-term SARS-CoV-2 infections, co-infections, and other pandemic potential viruses remains an ongoing and pressing issue. Indeed, these RNA viruses continue to evolve by persistently evading our immune defenses. One way that these viruses evade the immune system is by leveraging their viral suppressors of RNA (VSR) interference (RNAi) machinery to counteract the host’s own defense arsenal.