Supply chain resilience and economic, environmental, and social sustainability challenges are highly vulnerable and uncertain. Under the unprecedented supply chain disruption caused by epidemics such as COVID-19, many organisations face new challenges of shifting situation, managing volatility of information, and coordinating supply chain structures. During the pandemic crisis, corporations are presented with an opportunity to reconsider their global supply chain management and accelerate their capabilities for the long-term sustainability in managing current and future challenges. Corporate leaders and supply chain managers have major tasks to reduce supply chain uncertainty and risks, while balancing supply chain resilience and sustainability performance. By addressing the key question ‘can supply chain resilience and sustainability help companies survive and recover for business sustainability and continuity?’, this chapter presents important solutions and opportunities for corporate leaders and supply chain managers. This paper also offers new insights on how supply chain resilience and sustainability help companies to manage complex interdependency and related risks in supply chain.