Mir-3928 in Saliva as Potential Biomarker for Head and Neck Squamous Cell Carcinoma
File version
Author(s)
Wei, Ming
Nikolarakos, Dimitrios
Good, David
Nair, Raj
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
Vancouver, Canada
License
Abstract
Objectives: To determine whether salivary miR-3928 can be used for early head and neck cancer diagnostic purpose. Methods: The expression level of human salivary miR-3928 was investigated in 230 supernatant saliva samples. These samples were collected from head and neck squamous cell carcinoma (HNSCC) patients (n = 150) and healthy individuals (n = 80). Quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) was used to detect the expression level of the miRNA.
Results: Total RNA was isolated in average 160 ng/µl from 500 µl of supernatant saliva. Overall, miR-3928 expression was revealed to be correlated with HNC. We found that salivary miR-3928 was significantly down regulated in supernatant saliva of HNC patients (P< 0.05).
Conclusions: This study reported that down-regulate of miR-3928 could be used as salivary biomarker for HNSCC detection.
Journal Title
Conference Title
97th International Association of Dental Research (IADR) General Session
Book Title
Edition
Volume
Issue
Thesis Type
Degree Program
School
DOI
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Oncology and carcinogenesis
Persistent link to this record
Citation
Fadhil, R; Wei, M; Nikolarakos, D; Good, D; Nair, R, Mir-3928 in Saliva as Potential Biomarker for Head and Neck Squamous Cell Carcinoma, 2019