This study explores the relationships between motivation, service quality, tourist satisfaction, quality of life (QOL), and spa and wellness tourism. The partial least squares structural equation modeling (PLS-SEM) approach was used to analyze the hypotheses generated. The ‘snowball’ sampling technique was used to collect data via an online survey. Derived from a sample of 270 Chinese respondents, the results demonstrate that motivations positively impact service quality perception and tourist satisfaction, which in turn influence QOL. The tourists who perceived good spa and wellness services quality are more likely to be satisfied with their tourism experience. Furthermore, tourist satisfaction mediates the relationship between service quality and the QOL resulting from spa and wellness tourism.