Current Development of Nano-Drug Delivery to Target Macrophages
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Gao, Wendong
Li, Zhelun
Zhang, Yufeng
Xiao, Lan
Xiao, Yin
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Abstract
Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized.
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Biomedicines
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10
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5
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Pharmacology and pharmaceutical sciences
Biochemistry and cell biology
Medicinal and biomolecular chemistry
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Medicine, Research & Experimental
Pharmacology & Pharmacy
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Cai, D; Gao, W; Li, Z; Zhang, Y; Xiao, L; Xiao, Y, Current Development of Nano-Drug Delivery to Target Macrophages, Biomedicines, 2022, 10 (5), pp. 1203