3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next?
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Litfin, Thomas
Zhan, Jian
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Protein structure prediction has been a challenging problem for >60 years. Its progress has been considered incremental for the past 20 years until leaps were made by AlphaFold that seemed to suddenly reach experimental accuracy. We argue that this unexpected success in 3D structure prediction was foreshadowed by prior advances in predicting 1D backbone structures and 2D side-chain distance maps in continuous angle and distance space as well as the embedding of these 1D and 2D features for end-to-end learning.
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National Science Review
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10
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12
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© The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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Proteomics and metabolomics
Microbiology
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Zhou, Y; Litfin, T; Zhan, J, 3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next?, National Science Review, 2023, 10 (12), pp. nwad259