Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum

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Feng, Yunjiang
Davis, Rohan A
Sykes, Melissa L
Avery, Vicky M
Carroll, Anthony R
Camp, David
Quinn, Ronald J
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2010
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Abstract

Bioassay-guided fractionation of the crude CH2Cl2/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1-3 are potent antitrypanosomal agents with IC50 values of 0.077, 0.032, and 1.33 占against Trypanosoma brucei brucei, respectively.

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Tetrahedron Letters

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51

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18

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Medicinal and biomolecular chemistry

Biologically active molecules

Organic chemistry

Biochemistry and cell biology

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